Challenge to overcome current limitations of cell-penetrating peptides

Gyu Chan Kim; Dae Hee Cheon; Yan Lee

doi:10.1016/j.bbapap.2021.140604

Challenge to overcome current limitations of cell-penetrating peptides

Biochim Biophys Acta Proteins Proteom. 2021 Apr;1869(4):140604. doi: 10.1016/j.bbapap.2021.140604. Epub 2021 Jan 14.

Authors

Gyu Chan Kim¹, Dae Hee Cheon¹, Yan Lee²

Affiliations

¹ Department of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea.
² Department of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address: gacn@snu.ac.kr.

PMID: 33453413
DOI: 10.1016/j.bbapap.2021.140604

Abstract

The penetration of biological membranes is a prime obstacle for the delivery of pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver various cargos across the biological membranes. Since the discovery, CPPs have been rigorously studied to unveil the underlying penetrating mechanism as well as to exploit CPPs for various biomedical applications. This review will focus on the various strategies to overcome current limitations regarding stability, selectivity, and efficacy of CPPs.

Keywords: Antimicrobial peptides (AMPs); Cell penetrating peptides (CPPs); Drug delivery; Penetrating mechanism; Therapeutic applications.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Cell Membrane / metabolism
Cell-Penetrating Peptides / administration & dosage*
Cell-Penetrating Peptides / chemistry
Drug Delivery Systems
Humans
Pore Forming Cytotoxic Proteins / administration & dosage
Pore Forming Cytotoxic Proteins / chemistry

Substances

Cell-Penetrating Peptides
Pore Forming Cytotoxic Proteins