[HTML][HTML] Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication
M Ide, N Tabata, Y Yonemura, T Shirasaki… - Journal of Biological …, 2022 - ASBMB
Hepatitis B virus (HBV) infection is a major global health problem with no established cure.
Dedicator of cytokinesis 11 (DOCK11), known as a guanine nucleotide exchange factor
(GEF) for Cdc42, is reported to be essential for the maintenance of HBV. However, potential
therapeutic strategies targeting DOCK11 have not yet been explored. We have previously
developed an in vitro virus method as a more efficient tool for the analysis of proteomics and
evolutionary protein engineering. In this study, using the in vitro virus method, we screened …
Dedicator of cytokinesis 11 (DOCK11), known as a guanine nucleotide exchange factor
(GEF) for Cdc42, is reported to be essential for the maintenance of HBV. However, potential
therapeutic strategies targeting DOCK11 have not yet been explored. We have previously
developed an in vitro virus method as a more efficient tool for the analysis of proteomics and
evolutionary protein engineering. In this study, using the in vitro virus method, we screened …