Challenge to overcome current limitations of cell-penetrating peptides
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver
various cargos across the biological membranes. Since the discovery, CPPs have been
rigorously studied to unveil the underlying penetrating mechanism as well as to exploit
CPPs for various biomedical applications. This review will focus on the various strategies to
overcome current limitations regarding stability, selectivity, and efficacy of CPPs.
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver
various cargos across the biological membranes. Since the discovery, CPPs have been
rigorously studied to unveil the underlying penetrating mechanism as well as to exploit
CPPs for various biomedical applications. This review will focus on the various strategies to
overcome current limitations regarding stability, selectivity, and efficacy of CPPs.
Abstract
The penetration of biological membranes is a prime obstacle for the delivery of pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver various cargos across the biological membranes. Since the discovery, CPPs have been rigorously studied to unveil the underlying penetrating mechanism as well as to exploit CPPs for various biomedical applications. This review will focus on the various strategies to overcome current limitations regarding stability, selectivity, and efficacy of CPPs.
Elsevier