[HTML][HTML] A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
E Vives, P Brodin, B Lebleu - Journal of Biological Chemistry, 1997 - ASBMB
Tat is an 86-amino acid protein involved in the replication of human immunodeficiency virus
type 1 (HIV-1). Several studies have shown that exogenous Tat protein was able to
translocate through the plasma membrane and to reach the nucleus to transactivate the viral
genome. A region of the Tat protein centered on a cluster of basic amino acids has been
assigned to this translocation activity. Recent data have demonstrated that chemical
coupling of a Tat-derived peptide (extending from residues 37 to 72) to several proteins …
type 1 (HIV-1). Several studies have shown that exogenous Tat protein was able to
translocate through the plasma membrane and to reach the nucleus to transactivate the viral
genome. A region of the Tat protein centered on a cluster of basic amino acids has been
assigned to this translocation activity. Recent data have demonstrated that chemical
coupling of a Tat-derived peptide (extending from residues 37 to 72) to several proteins …